Retrospective Evaluation of the Impact of a Multidisciplinary One‐Year Online Lifestyle Intervention on Type 2 Diabetes Remission in Nonobese Indian Patients

Background and Objective: Despite the high prevalence of T2D among nonobese Indians, there is a notable lack of comprehensive lifestyle intervention studies that target this population. This retrospective study was aimed at filling this gap by evaluating the impact of a multidisciplinary 1‐year online intensive lifestyle intervention (ILI) on T2D remission in nonobese Indian patients. Methodology: Retrospective data from medical records of 1453 nonobese patients (BMI 18.5–24.9 kg/m 2 ) (aged > 18 years) who participated in a 1‐year online subscription‐based ILI program at the Freedom from Diabetes Clinic, India, between June 2020 and October 2023 were extracted for analysis. The program included a plant‐based diet, physical activity regimens, psychological support, and medical management. Homeostatic model assessment of insulin resistance (HOMA2‐IR) and beta cell function (HOMA2%B) were calculated. Remission was defined as maintaining glycated hemoglobin (HbA1C) < 6.5%, measured at least 3 months after cessation of glucose‐lowering pharmacotherapy. Results: The study included 1453 patients (72% male), with a median age of 53 years (IQR: 15), BMI of 23 kg/m 2 (IQR: 2.2), and diabetes duration of 10.5 years (IQR: 10.4). Postintervention, significant changes were observed, including a reduction in weight (−1.5 kg), fasting blood glucose (−13.2 mg/dL), fasting insulin (−0.4 μ U/mL), HOMA2‐IR (−0.07), and HbA1c (−1.2%), along with an increase in HOMA2%B (+3.1) ( p < 0.05). Remission was observed in 24% of the patients. The study identified the baseline predictors of remission as being over 40 years of age at onset, having a diabetes duration of less than 6 years, maintaining good glycemic control (HbA1C ≤ 7%), and being drug‐naïve. Postintervention factors, such as weight loss and improved beta cell function, were also significant predictors of remission ( p < 0.05). Conclusion: These findings suggest that a multidisciplinary lifestyle intervention program can significantly improve glycemic control and promote T2D remission in nonobese Indian patients in a real‐world setting, thereby highlighting the importance of early intervention and weight management in this population. Trial Registration: Clinical Trials Registry of India identifier: CTRI/2024/03/064596