Comparative assessment of the combined action of chlorsulfuron-based pesticides

Introduction. For several decades, herbicides have remained effective means of weed control, accounting for more than 60% of registered pesticide preparations. Among modern herbicides, combination preparations are popular. The range of combination preparations continues to increase, and currently there are more than fifty different names. Given the specific features of the joint interaction of pesticides, the requirements for their toxicological and hygienic assessment are increasing from year to year. Materials and methods. To establish the nature of the combined action of chlorsulfuron with other active substances and study the nature and degree of interaction of these substances, the method of orthogonal experimental design using probability values was used. Results. Based on the results of the studies, toxicity parameters were established and the nature and degree of interaction of various combinations of chlorsulfuron with other active substances: 2,4-D and dicamba were determined. Limitations. When choosing toxicometric parameters for chlorsulfuronic acid, the intragroup number of rats is 6–10 individuals, depending on the tasks being solved, which is a sufficient reference sample. Conclusion. The parameters of acute oral toxicity were established and the interdependent additive nature of the combined action of chlorsulfuron with other active substances was determined upon a single oral administration to the body of laboratory animals.