Reviewing The Role of Topical Tranexamic Acid to Accelerate Wound Healing

Introduction: Wound healing involves a dynamic series of events, including hemostasis, inflammation, proliferation, and remodeling. Clinicians have traditionally used Tranexamic Acid (TXA) for its antifibrinolytic effects in bleeding control. Recently, researchers have investigated its topical application to enhance wound healing. Methods: We conducted a structured literature review using PubMed, Scopus, and Google Scholar, focusing on studies evaluating the effects of topical tranexamic acid (TXA) on wound healing. We selected preclinical and clinical studies that assessed healing outcomes, mechanistic pathways, and safety profiles. Results: Topical tranexamic acid (TXA) modulates fibrinolysis by inhibiting plasmin activity, which stabilizes the fibrin matrix and reduces local inflammation. Studies report that tranexamic acid (TXA) enhances fibroblast proliferation, promotes angiogenesis, and accelerates epithelialization. Animal models show faster wound closure and improved collagen deposition. Clinical trials in surgical, diabetic, and chronic wounds demonstrate reduced healing time, improved scar quality, and lower infection risk. Most studies report no significant adverse events when tranexamic acid (TXA) is used topically at safe concentrations. Discussion: Current evidence suggests that topical tranexamic acid (TXA) not only controls bleeding but also accelerates tissue repair through multiple biological mechanisms. Despite promising findings, researchers must conduct larger, controlled studies to confirm these benefits and establish standard protocols.