Observational analysis shows adherence to linear proliferation in genetically modified Escherichia coli, suggesting potential for better control over microbial behavior.
Uncurbed exponential proliferation might not always be required for genetically modified microorganisms, and might even cause unpredictable liabilities in their behavior and impact. We therefore constructed a bacterial chassis that adheres to linear proliferation for a finite number of generations, based on the asymmetric segregation of a gradually declining intracellular protein aggregate that is engineered to produce a conditionally essential metabolite such as cAMP.
No takes yet. Share an insight, caveat, or question.
Eyken et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: