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August 23, 2025DiagnosticsOpen Access

The Diagnostic Utility of Prenatal Microarray in High-Risk Pregnancies: A Single-Center Experience in Enhancing Reproductive Care and Risk Stratification

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Authors

ABAbdüllatif BakırTurkish Armed ForcesMAMustafa Tarık AlayTurkish Armed ForcesUTUmut Can TekbaşTurkish Armed Forces

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Implication

Single-center analysis shows microarray detects chromosomal abnormalities in high-risk pregnancies, supporting prenatal testing improvements.

Key Points

  • CMA identifies chromosomal abnormalities in 16.5% of high-risk pregnancies, revealing critical diagnostic information.
  • The study analyzed 344 prenatal samples, enhancing detection of submicroscopic CNVs that conventional methods miss.
  • By utilizing SNP-based CMA on the Infinium platform, significant insights into fetal structural anomalies were achieved.
  • These findings highlight the need for routine implementation of CMA in prenatal genetic evaluations for better outcomes.

Cite This Study

Bakır et al. (2025) studied this question.

synapsesocial.com/papers/68af5bc7ad7bf08b1eadff60https://doi.org/10.3390/diagnostics15172129
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Also Consider

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  1. 1Committee Opinion No. 5812013 · 115 citations
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  3. 3Chromosomal microarray impacts clinical management2013 · 91 citations
  4. 4Chromosomal Microarray versus Karyotyping for Prenatal Diagnosis2012 · 1,444 citations
  5. 5Potentials and challenges of chromosomal microarray analysis in prenatal diagnosis2022 · 39 citations