What type of study is this?

This is a Meta-Analysis study (also classified as: Observational).

August 24, 20250 citationsOpen Access

Genomic Insights into Externalizing Disorders and Suicide Risk

A Multivariate Genomic Investigation of the Externalizing Spectrum and Suicide Risk

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Authors

PBPeter B. Barr MSMallory Stephenson HPHolly E. Poore

Discussion

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Overview

Multivariate analysis reveals significant genetic links between externalizing disorders and suicide risk in veterans, suggesting a need for focused interventions.

Key Points

MVP-EXT has a strong genetic correlation with prior externalizing factors and suicide attempts, indicating shared risk pathways.
Meta-analysis identified 155 loci associated with externalizing traits and suicidal behavior among 310,498 European-like and 99,949 African-like veterans.
Genomic structural equation modeling methods highlight the genetic overlap between externalizing disorders and various suicide outcomes.
A phenotypic externalizing score prospectively predicts higher suicide risk, emphasizing the importance of addressing these disorders.

Cite This Study

Barr et al. (2025) studied this question.

synapsesocial.com/papers/68af5d5dad7bf08b1eae02a1 https://doi.org/10.1101/2025.08.19.25332327

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August 24, 20250 citationsOpen Access

Genomic Insights into Externalizing Disorders and Suicide Risk

A Multivariate Genomic Investigation of the Externalizing Spectrum and Suicide Risk

View Full Paper

Ask AI

Bookmark

Authors

PBPeter B. Barr MSMallory Stephenson HPHolly E. Poore

Discussion

Member takes

Overview

Multivariate analysis reveals significant genetic links between externalizing disorders and suicide risk in veterans, suggesting a need for focused interventions.

Key Points

MVP-EXT has a strong genetic correlation with prior externalizing factors and suicide attempts, indicating shared risk pathways.
Meta-analysis identified 155 loci associated with externalizing traits and suicidal behavior among 310,498 European-like and 99,949 African-like veterans.
Genomic structural equation modeling methods highlight the genetic overlap between externalizing disorders and various suicide outcomes.
A phenotypic externalizing score prospectively predicts higher suicide risk, emphasizing the importance of addressing these disorders.

Cite This Study

Barr et al. (2025) studied this question.

synapsesocial.com/papers/68af5d5dad7bf08b1eae02a1 https://doi.org/10.1101/2025.08.19.25332327

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