⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

August 25, 2025Kırıkkale Üniversitesi Tıp Fakültesi DergisiOpen Access

Reserpine Enhances the Genotoxic Effects of Doxorubicin in Hepatocellular Carcinoma Cells

Sümeyra Özdoğru Serkan S. Şengül Emrah Sayın Beyza Nur Biçer Sinem Arslan Zülal Bucak Erkan Yurtçu

View Full Paper

Ask AI

Bookmark

Share

Key Points

Doxorubicin and reserpine significantly increased DNA damage in HepG2 cells, indicating enhanced genotoxic effects.
The IC50 value of reserpine was determined via the MTT method, contributing to its anticancer properties.
Cells were treated with doxorubicin and reserpine separately and in combination to evaluate the effects on DNA damage.
This study highlights how reserpine may overcome drug resistance in hepatocellular carcinoma, warranting further investigation.

No abstract yet

We only have this paper's title and publication details.

Read it at the source→

Implication

In vitro analysis reveals reserpine enhances DNA damage caused by doxorubicin in HepG2 cells, suggesting a potential combination therapy approach.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Özdoğru et al. (2025) studied this question.

synapsesocial.com/papers/68af5d63ad7bf08b1eae08af https://doi.org/10.24938/kutfd.1693317

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Doxorubicin Cytotoxicity and Mitochondrial Changes in Human Proximal Tubular Epithelial Cells (HK‐2) is Partially Prevented by Resveratrolpreclinical · 2021 · 1 citations
2Comparative Studies of Resveratrol, Oxyresveratrol and Dihydrooxyresveratrol on Doxorubicin-Treated Lung Cancer Cells2024 · 7 citations
3Additive effects of resveratrol and doxorubicin on bladder cancer cellspreclinical · 2021 · 12 citations
4The beneficial efficacy of liposomal resveratrol against doxorubicin-induced hepatotoxicity in rats: Role of TGF-β1 and SIRT1preclinical · 2021 · 12 citations
5Apigenin and hesperidin augment the toxic effect of doxorubicin against HepG2 cellspreclinical · 2019 · 64 citations

More related papers

Reserpine Induces Apoptosis in Drug-Resistant Cancer through Modulating STAT3 and NF-κB Signaling2024
Chemosensetizing and cardioprotective effects of resveratrol in doxorubicin- treated animals2013
Resveratrol inhibits doxorubicin-induced cardiotoxicity via sirtuin 1 activation in H9c2 cardiomyocytes2016

More from Kırıkkale Üniversitesi Tıp Fakültesi Dergisi

Müni̇h Kronoti̇p Anketi̇ Vardi̇yali Çalişanlar Formu'nun (Mctqshift) Türkçeye Uyarlanmasi: Sağlik Çalişanlarinda Bi̇r Geçerli̇k ÇalişmasiWed,
Prognostic Value of Lactate Levels, Bicarbonate, and Leukocyte-Glucose Index in Early Mortality Prediction in Methanol PoisoningWed,