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August 25, 2025Open Access

EaMIC3 inhibits cell apoptosis and facilitates Eimeria acervulina infection through interacting with EpCAM

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Authors

YZYadong ZhengZhejiang A & F UniversityWPWenyuan PuNanjing Children's HospitalZRzhang renzhe

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Implication

Experimental findings show that EaMIC3 interacts with EpCAM to enhance Eimeria acervulina infection, suggesting a potential target for coccidiosis therapy.

Key Points

  • EaMIC3 inhibits apoptosis in infected cells and promotes Eimeria acervulina infection through EpCAM interaction.
  • A maximum oocyst reduction rate of 67.86% was observed with pooled EaMIC3 and EpCAM antisera.
  • The interaction between EaMIC3 and EpCAM is mediated by three microneme adhesive repeat regions, influencing cell signaling.
  • Knockdown of EpCAM inhibited sporozoite infection, while its overexpression had the opposite effect.

Cite This Study

Zheng et al. (2025) studied this question.

synapsesocial.com/papers/68af5d6fad7bf08b1eae1125https://doi.org/10.21203/rs.3.rs-7302653/v1
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Toxoplasma gondii ME-49 strain upregulates levels of A20 that inhibit NF-κB activation and promotes apoptosis in human leukaemia T-cell lines2018 · 15 citations
  2. 2Comparison of circulating tumor cell (CTC) detection rates with epithelial cell adhesion molecule (EpCAM) and cell surface vimentin (CSV) antibodies in different solid tumors: a retrospective study2021 · 60 citations