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August 25, 2025European journal of medical researchOpen Access

Nrf2 pathway potentially confers protection against cigarette smoke-induced sarcopenia in a mouse model

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Authors

PGPin GuanWCWentao CaiCZChunrong Zhong

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Overview

Mouse model demonstrates that Nrf2 signaling reduces oxidative stress and inflammation in COPD-related sarcopenia, suggesting therapeutic potential.

Key Points

  • The Nrf2 pathway significantly reduces muscle injury related to COPD, indicating a protective effect against sarcopenia.
  • Cigarette smoke exposure in mice led to muscle mass loss and weakened grip strength, with inflammation markers elevated.
  • Assessment involved various techniques including Western blotting and flow cytometry to analyze Nrf2's role in muscle function.
  • Sulforaphane treatment enhanced Nrf2 signaling, while its inhibition with ML385 had adverse effects, highlighting its regulatory importance.

Cite This Study

Guan et al. (2025) studied this question.

synapsesocial.com/papers/68af5f07ad7bf08b1eae16d9https://doi.org/10.1186/s40001-025-03079-0
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