Synthesis shows high enantioselective recognition toward chiral drug intermediates, highlighting the significance of abundant binding sites.
Chiral macrocycles R/S-C with abundant recognition sites were synthesized via a simple four-step reaction procedure. These homochiral macrocycles can be easily purified by silica gel column chromatography without the demand for chiral separation. Their structures have been carefully characterized using X-ray crystallography and NMR spectroscopy. R/S-C exhibits enantioselective recognition toward a class of chiral drug intermediates, with an enantioselectivity reaching up to 9.6.
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Zhang et al. (2025) studied this question.
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