Base-controlled diastereoselective [3+2]-cycloaddition and Michael addition of isatin ketonitrones and chalcones to construct spiropyrrolidine oxoindoles and γ-substituted isatin ketonitrones

The synthesis of novel spiropyrrolidine oxoindole/γ-substituted isatin ketonitrone derivatives was reported, using [3+2]-cycloaddition/Michael addition of isatin ketonitrones 1,3-dipoles, generated from the condensation of isatins and arylhydroxylamines, with chalcones under base-controlled...