Review highlights CRISPR-dCas9's potential in targeting cancer through epigenetic modification, suggesting advancements may improve treatment outcomes.
Cancer appears and develops not only related to genes but also takes an important role in epigenetic regulation. In recent years, CRISPR-dCas9 as a new precision gene-editing tool has aroused much attention because it can combine with epigenetic effectors to regulate cancer-related genes specifically. It shows great prospects for treating a wide variety of diseases, particularly for epigenetic modifications of cancer. This article reviews the biochemistry of CRISPR-dCas9 systems and their use in epigenetic modification of cancer, focusing on how DNA methylation, histone modification, etc., affect tumorigenesis. In addition, the recent progress, challenges, and prospects of CRISPR-dCas9 mediated epigenetic editing technology for cancer gene therapy are also presented. By analyzing the current problems encountered in the clinical translation of CRISPR-dCas9 technology, this article has shown that CRISPR-dCas9 technology has the potential to become a targeted cancer treatment, which can also provide references for future medical research.
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Binglin Ye (2025) studied this question.
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