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Evaluation of 5B9 as a Calibrator or Expression of Results in Absorbance Values for the Diagnosis of Hit With a PF4/Heparin Specific Elisa

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Analysis reveals that 5B9 calibration does not improve hit detection accuracy in patients, suggesting reliable exclusion can still occur.

Calibration of HPIA with 5B9 did not improve HIT detection accuracy, as AUC values remained similar when comparing OD and equivalent units.
Applying an OD threshold of 1.05 yielded a negative predictive value of 98% and a positive predictive value of 83% in diagnosing HIT.
In 170 patients assessed, HIT was confirmed in 43 cases based on positive HPIA and SRA/PF4 tests, emphasizing the importance of OD values.
Bayesian analysis indicates an OD of less than 1 results in a 1% post-test probability of HIT, while over 2 ensures a 100% probability.

Pouplard et al. (2025) studied this question.

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