Targeting the selectivity filter to drastically alter the activity and substrate spectrum of a promiscuous metal transporter

Yuhan Jiang; Michael Nikolovski; Tianqi Wang; Keith MacRenaris; Thomas V. OˈHalloran; Jian Hu

doi:10.1039/d5sc03700j

January 1, 2025Chemical ScienceOpen Access

Targeting the selectivity filter to drastically alter the activity and substrate spectrum of a promiscuous metal transporter

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Key Points

Targeting the selectivity filter can significantly enhance the activity of promiscuous metal transporters, allowing for tailored applications.
Key evidence shows that engineered d-block metal transporters demonstrate altered substrate specificity and transport abilities.
An engineering approach focusing on the selectivity filter was employed to modify metal transporter activity, leading to promising results.
These findings highlight the potential for selectively enriching or excluding metals in living organisms through tailored transporter modifications.

Implication

Targeting the selectivity filter enhances the activity and substrate spectrum of metal transporters, suggesting potential for broader applications.

Abstract

d-Block metal transporters are attractive engineering targets for selectively enriching or excluding metals in living organisms. However, systematic efforts to engineer these transporters have been hindered by limited knowledge on...

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Cite This Study

Jiang et al. (2025) studied this question.

synapsesocial.com/papers/68af63ddad7bf08b1eae3fc3 https://doi.org/10.1039/d5sc03700j

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Targeting the selectivity filter to drastically alter the activity and substrate spectrum of a promiscuous metal transporter

Key Points

Implication

Abstract

Discussion

Cite This Study

Targeting the selectivity filter to drastically alter the activity and substrate spectrum of a promiscuous metal transporter

Key Points

Implication

Abstract

Discussion

Cite This Study

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