P126 | Heart involvement in hypothyroidism: a myocardial work study

Introduction: From 2022 Guideline for Management of Heart Failure it’s known that hypothyroidism is a potential cause of heart failure.Aim: Clarify the hemodynamic changes caused by hypothyroidism using myocardial work, an emerging echocardiographic tool.Materials and Methods: Study population includes 48 patients with hypothyroidism in absence of cardiovascular risk factors and 102 healthy controls with euthyroidism. Myocardial work assessment was performed with EchoPAC. Four values are calculated: global work index (GWI), global constructive work (GCW), global wasted work (GWW) and global work efficiency (GWE). Continuous normally distributed variables were compared by using the Student t-test. Probability value <0.05 was considered significant.Results: In hypothyroidism patients a significant increase in left ventricular mass indexed, a significant reduction in ejection fraction, a significant worsening of diastolic parameters were found; regarding myocardial work, a significant increase in GWW was found with a significant reduction in GWI, GCW and GWE. A comparison analysis was carried out in the group of hypothyroid patients subdividing them on the basis of TSH and showed a statistically significant reduction in GWE and increase in GWW in patients with TSH >10.Conclusions: This study highlights how thyroid function plays a central role in regulating cardiac performance and the importance of early diagnosis and treatment of thyroid diseases in patients with heart failure.