Literature Review: The Role of NRXN-3 and Neurexin-3 Proteins in the Mechanisms of Schizophrenia

Schizophrenia is a neuropsychiatric disorder which affects more than 26 million people worldwide, impacting thought and perception. A combination of neural, genetic, and environmental factors make up its etiology. The gene NRXN3 has been studied for its role in the symptoms and development of schizophrenia. NRXN3 translates into 2 postsynaptic proteins which are involved with synapse formation: alpha and beta neurexin-3. Neurexin-3 proteins play a role in synapse formation, differentiation, plasticity, and regulation of inhibitory and excitatory synapses, all of which are impacted in schizophrenia. Further investigation of NRXN3 and its role in schizophrenia may lead to the development of more efficient and antipsychotic and therapeutic medications for patients.