Pudendal Nerve Mapping in Humans v1

The goal of this study is to map the pudendal nerve with imaging and electrophysiology by gathering additional data from patients receiving an implanted neurostimulator as part of their normal clinical care, and to examine the response of the bladder and urethra to different pudendal nerve stimulation frequencies in humans. There are 5 main parts to this study. Participants complete pre and post study questionnaires to asses their pelvic health and functional change. Volumetric imaging with MRI and CT scans are done to create patient specific maps of each participant's pelvic anatomy. Additional details on the parameters used for the MRI and CT scans can be found here:dx.doi.org/10.17504/protocols.io.yxmvm978bl3p/v1. During device implantation experimental trials are performed in the OR to asses the impact of different simulation parameters on the pelvic floor. After device implantation experimental trials are performed during a cystometrogram to asses how bladder state and stimulation parameters affect pelvic floor and lower urinary tract function.