Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 28, 2023Pakistan Journal of Medical & Health Sciences

Molecular Biomarkers for Prenatal Diagnosis of Beta-Thalassemia at Hyderabad Sindh

View Full Paper
Ask AI
Bookmark
Share

Authors

SASumera AbbasiLiaquat University of Medical & Health SciencesVKVershia KanwalBBBenazeer BhattiLiaquat University of Medical & Health Sciences

Discussion

Loading...

Member takes

Overview

Investigation reveals common mutations in beta globin gene among thalassemia patients, indicating potential for prenatal diagnosis.

Key Points

  • Beta thalassemia patients exhibited significantly lower hemoglobin levels compared to controls, and reduced MCV and MCH values were observed.
  • Mutation analysis showed IVS-1-5 (42.5%) and Fr 8/9 (27%) as the most common mutations in thalassemia patients from Hyderabad.
  • ARMS PCR method was utilized for detecting mutations, collecting data from blood samples to evaluate beta thalassemia cases.
  • This research supports the need for accessible molecular diagnostics in prenatal care for thalassemia management.

Cite This Study

Abbasi et al. (2023) studied this question.

synapsesocial.com/papers/68af65a1ad7bf08b1eae5d50https://doi.org/10.53350/pjmhs020231712519
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Molecular Detection of Five Types of Thalassemia Mutations among Patients with Β-Thalassemia in Northern Basrah Regions Using ARMS PCR Technology2024
  2. 2An Immunological and Molecular Study to Investigate the Genes (β-globin and HBA1F) in Patients with Thalassemia in Najaf Governorate2024 · 1 citations
  3. 3Mutation Analysis of Exon 1 in the Hemoglobin Subunit Beta (HBB) Gene in Beta-Thalassemia2024 · 1 citations
  4. 4Beta-Thalassemia Haplotypes in Southwest of Iran2024
  5. 5MOLECULAR PATHOLOGY OF Β-THALASSEMIA: CLINICOGENETIC EVALUATION OF HBB GENE MUTATIONS IN AFFECTED POPULATIONS: A CROSS-SECTIONAL STUDY2025