Total Synthesis of (±)-Lycojapomines A and B

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This is a In Vitro Study study.

doi:10.1055/a-2653-4680

August 27, 2025SynfactsOpen Access

Total Synthesis of (±)-Lycojapomines A and B

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Key Points

Total synthesis achieved for both lycojapomines A and B, showcasing effective use of innovative chemical reactions.
Key techniques included photoinduced radical cyclization and ozonolysis, crucial for the successful synthesis.
Approach involved specific cyclization methods, specifically 5-endo-dig cyclization and aza-silyl-Prins reaction, to form desired compounds.
Significance lies in advancing synthesis methods for lycopodium alkaloids, highlighting potential for drug development.

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Implication

Total synthesis of lycojapomines A and B employs photoinduced radical cyclization, suggesting new paths for alkaloid production.

Abstract

Keywords (±)-lycojapomine A and B - lycopodium alkaloids - photoinduced radical cyclization - 5-endo-dig cyclization - aza-silyl-Prins reaction - ozonolysis

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A 2025 study studied this question.

synapsesocial.com/papers/68b033590a36ac2c8db3ccba https://doi.org/10.1055/a-2653-4680

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Total Synthesis of (±)-Lycojapomines A and B

Key Points

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Implication

Abstract

Discussion

Cite This Study

Total Synthesis of (±)-Lycojapomines A and B

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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