Imagenomics and Ventricular Arrhythmia

Imagenomics is an emerging clinical framework that combines advanced imaging and genetic profiling to refine risk stratification and advance precision medicine in the management of ventricular arrhythmias. A 43-year-old woman presented with palpitations and presyncope. Ambulatory electrocardiogram revealed frequent premature ventricular contractions and nonsustained ventricular tachycardia, consistently initiated by a premature ventricular contraction with distinct morphology. Cardiac magnetic resonance scan identified a nonischemic scar in the basal inferolateral segment of the left ventricle, with a protected conduction corridor of heterogeneous tissue within the border zone. Electroanatomic mapping confirmed a critical isthmus that was anatomically colocalized with the cardiac magnetic resonance-defined corridor. Programmed ventricular stimulation induced sustained monomorphic ventricular tachycardia that degenerated into ventricular fibrillation, necessitating implantable cardioverter-defibrillator placement. Genetic analysis revealed a heterozygous, likely pathogenic TECRL variant, associated with catecholaminergic polymorphic ventricular tachycardia type 3. This case highlights a composite arrhythmogenic mechanism shaped by myocardial scar substrate, protected conduction architecture, and inherited susceptibility.