Single-cell RNA sequencing uncovers impaired urothelial-fibroblast crosstalk in ureteral stricture, suggesting new therapies.
Key Points
Impaired crosstalk between urothelial cells and fibroblasts correlates with increased ureteral stricture risk, indicating a pivotal role in its pathogenesis.
Single-cell RNA sequencing revealed significant downregulation of urothelial gene signatures in tissues from patients with ureteral stricture compared to normal ureters.
Fibroblasts in the ureteral stricture tissues showed reduced expression of key fibroblast receptors, suggesting disrupted signaling that could contribute to fibrotic remodeling.
The research highlights ANXA1 as a crucial ligand in maintaining fibroblast homeostasis through its communication with urothelial cells, emphasizing potential therapeutic targets.