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September 5, 2025Open Access

Trends in Sepsis-Related Mortality among Individuals with Liver Disease in the United States: 1999–2020

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Authors

LKLaksh KumarSJSahil JairamaniMKMaliha Khalid

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Overview

Analysis reveals significant increases in sepsis-related mortality for liver disease patients, suggesting demographic disparities and geographic challenges.

Key Points

  • Sepsis-related mortality has significantly increased among individuals with liver disease, particularly after 2009.
  • American Indian/Alaska Native populations have the highest mortality rates, with alarming increases in Black/African American communities.
  • Observational analysis using CDC WONDER data highlighted trends in mortality rates stratified by sex, race/ethnicity, and geographic location.
  • Findings underscore the need for targeted public health interventions addressing systemic disparities in healthcare access.

Cite This Study

Kumar et al. (2025) studied this question.

synapsesocial.com/papers/68bb3d5b2b87ece8dc9561b1https://doi.org/10.22541/au.175636446.69445587/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sepsis-related mortality in adults with liver and intrahepatic bile duct malignancies: A 25-year national analysis of trends and disparities, 1999-2023.2026
  2. 2Temporal trends in U.S. mortality from liver cirrhosis and sepsis: A 25-year retrospective analysis (1999–2023)2026
  3. 3Geodemographic trends and disparities in liver cancer and sepsis-related mortality among adults aged ≥ 45 years in the United States, 1999-2024: A CDC WONDER analysis.2026
  4. 4Temporal Trends and Disparities in Mortality Due to Sepsis and Ischemic Heart Disease in the United States Adults 1999–2023: A Retrospective Analysis2026
  5. 5Evolving Trends and Disparities in Chronic Kidney Disease and Sepsis-Related Mortality in the United States from 1999 to 20232025