Total synthesis reveals how a change in stereocenter impacts biological activity of dahurelmusin A and its epimer.
Reported herein is a total synthesis of the peptide-polyketide natural product dahurelmusin A along with its C10 epimer (epi-dahurelmusin A). The syntheses benefited from well-established aldol and macrocyclization technologies. Access to the natural product and its C10 epimer provided opportunities to test the importance of the C10 stereocenter in the biological activity of the natural product.
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Okada et al. (2025) studied this question.
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