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September 5, 2025Science

Deep generative models design mRNA sequences with enhanced translational capacity and stability

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Authors

HZHe ZhangHLHailong LiuYXYushan Xu

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Overview

GEMORNA shows a significant increase in mRNA expression in vitro, highlighting its potential for therapeutics.

Key Points

  • GEMORNA-designed mRNAs achieved up to a 41-fold increase in firefly luciferase expression in vitro.
  • Therapeutic mRNAs generated showed a 15-fold enhancement in EPO expression and elicited robust antibody titers in mice.
  • The use of deep generative models exhibits vast potential for advancing mRNA therapeutics.
  • GEMORNA enhances circular RNA expression and anti-tumor cytotoxicity in CAR-T cell models.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68bb3ef02b87ece8dc95741fhttps://doi.org/10.1126/science.adr8470
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