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Observational analysis evaluates CFTR activity in live cells using I-Sense, indicating a new tool for diagnostics.
Cystic fibrosis (CF) arises from mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Monitoring I- transport serves as a critical approach for evaluating CFTR function in live cells, providing a foundation for the development of diagnostic tools and therapeutic treatments. Here, we report an iridium(iii) complex (I-Sense) for the selective and pH-independent imaging of intracellular I-. By tracking cellular iodide I- uptake, I-Sense facilitates the evaluation of CFTR activity in live cells, providing a valuable tool for the functional characterization of CFTR activity.
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Morse et al. (2025) studied this question.
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