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September 5, 20250 citationsOpen Access

MCL1's Role in Chemoresistance Reexamined: Evidence Against Mediation

MCL1 may not mediate chemoresistance

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Authors

KEKylin A. EmhoffKCKunho ChungDZDongmei Zhang

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Overview

Observational analysis finds no support for MCL1's role in chemoresistance in cancer cells, suggesting nuclear functions may not influence drug response.

Key Points

  • MCL1 does not enhance chemoresistance in cancer cells, contradicting prior assumptions about its role.
  • Using monoclonal antibodies and proximity biotinylation, no evidence was found of MCL1 accumulating in the nucleus after drug exposure.
  • Prior studies suggested MCL1's nuclear functions involve cell cycle progression and DNA repair, but this research reveals no recovery of related partners.
  • The findings highlight the need for further investigation into the functional significance of MCL1 in the nuclear context.
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Cite This Study

Emhoff et al. (2025) studied this question.

synapsesocial.com/papers/68bb420d2b87ece8dc958247https://doi.org/10.1101/2025.08.22.671824
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