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September 5, 2025Scientific ReportsOpen Access

Effect of GLP-1RA on coronary progression and cardiovascular outcomes in type 2 diabetic patients after PCI: a prospective cohort study

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Authors

HZHuasu ZengJHJingchao HuZYZhuo Yang

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Overview

Prospective cohort study shows GLP-1RA reduces MACEs in 1664 type 2 diabetes patients after PCI, indicating potential benefits for coronary artery disease management.

Key Points

  • GLP-1RA treatment significantly reduced major adverse cardiovascular events (MACEs) in patients with type 2 diabetes after PCI.
  • The incidence of MACEs was lower at 7.63% in the GLP-1RA group versus 19.85% in the control group, with a hazard ratio of 0.444.
  • Prospective cohort analysis included 1664 patients who underwent PCI, highlighting the study's extensive participant base.
  • These findings suggest that GLP-1RAs could positively influence cardiovascular outcomes and delay coronary lesion progression.

Cite This Study

Zeng et al. (2025) studied this question.

synapsesocial.com/papers/68bb42212b87ece8dc958b6fhttps://doi.org/10.1038/s41598-025-17574-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of GLP-1RA Treatment on Long-Term Post-PCI Prognosis in T2DM Patients: A Propensity Score Matching Study2025
  2. 2GLP1 receptor agonists and CAD regression in diabetic patients after ACS2025
  3. 3Effects of glucagon‐like peptide‐1 receptor agonists on major coronary events in patients with type 2 diabetes2023 · 9 citations
  4. 4Cardiovascular and Renal Outcomes of GLP-1 Receptor Agonists in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis2026 · 2 citations
  5. 5GLP-1 Receptor Agonists for Secondary Prevention After Myocardial Infarction and Stroke in Type 2 Diabetes: Nationwide Real-World Evidence2026 · 7 citations