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September 5, 2025Cancer ControlOpen Access

Density and Maturity of Tertiary Lymphoid Structures Predict Clinical Outcome in Invasive Lung Adenocarcinoma

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Authors

YHYanyan HuangFHFei HuangXZXinyue Zhang

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Overview

Retrospective analysis associates intratumoral and peritumoral TLS characteristics with prognosis in invasive lung adenocarcinoma, indicating critical outcomes.

Key Points

  • Patients with higher intratumoral TLS density showed better overall survival.
  • Increased maturity of TLSs indicates worse prognosis for patients with invasive lung adenocarcinoma.
  • Pathological subtypes like solid and micropapillary correlate with lower intratumoral TLS density.
  • Multivariate analysis revealed TLS characteristics as significant independent prognostic factors for IAC outcomes.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68bb46b56d6d5674bccfe8d4https://doi.org/10.1177/10732748251372684
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