Systematic review analyzes pharmacological properties and formulations of Rosmarinus officinalis, suggesting innovation challenges.
This study performs a systematic review of scientific and technological data on Rosmarinus officinalis essential oil (Ro-EO) and its application in nanostructured formulations. The research highlights the importance of nanotechnological delivery systems to increase solubility, prolong systemic circulation, and control drug release. The main constituents of Ro-EO include 1,8-cineole, α-pinene, and camphor. However, patent analysis has revealed a limited amount of technologies developed for nanoformulations containing Ro-EO. Since 2017, there has been a slowdown in Brazilian innovation related to Ro-EO, possibly due to less interest in new technologies related to essential oil. The reasons for this slowdown deserve further investigation, considering that Ro-EO already has commercial viability, due to its pharmacological properties and low toxicity, making it promising for future applications.
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Ferraz et al. (2025) studied this question.
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