Higher Monocyte/Lymphocyte Ratio Is Associated with Impaired Glomerular Function and Cardiac Remodeling in Elderly Patients with Atrial Fibrillation: A Retrospective Study

To evaluate the association of the inflammation marker, such as monocyte/lymphocyte ratio (MLR), with adverse cardiac remodeling and clinical biochemical indexes in atrial fibrillation (AF) patients, this study investigated the association of MLR with clinical biochemical indexes and cardiac remodeling in elderly with AF. In a cross-sectional study, a total of 1154 hospitalized Chinese elderly (aged ≥ 65 years) with AF were collected retrospectively in a single medical care center. The patients were divided into low (≤ 0.293), moderate (> 0.293 to ≤ 0.460) and high (> 0.460) MLR ratio groups according to the tertiles of MLR. Regression analysis of MLR (> 0.460) with clinical biochemical indexes and echocardiographic parameters has been done. It revealed that high MLR (> 0.460) was independently associated with male gender, decreased estimated glomerular filtration rate (eGFR), lower level of plasma albumin, cardiac ventricular dilatation and dysfunction (All P < 0.05). In conclusion, high MLR was linked to male gender, decreased eGFR, lower plasma albumin level and adverse cardiac remodeling in elderly with AF.