Figure 1 from GPSai: A Clinically Validated AI Tool for Tissue of Origin Prediction during Routine Tumor Profiling

Hassan Ghani; Anthony Helmstetter; Jennifer R. Ribeiro; Todd Maney; Stephanie Rock; Rebecca Feldman; Jeffrey Swensen; Farah Abdulla; David Spetzler; Elena Florento; Ari M. Vanderwalde; Patricia Pittman; Milan Radovich; Jaclyn F. Hechtman; Casey Bales; George W. Sledge; Myra M. George; David Bryant; Jim Abraham; Matthew J. Oberley

doi:10.1158/2767-9764.30022019

Key Points

The AI tool accurately predicts tissue of origin for routine tumor profiling, improving diagnostics.
Validation involved over 201,000 samples, including 21,106 for retrospective checks and 6,820 TCGA cases for external validation.
Observational analysis used multiple validation cohorts, showcasing robustness across varied specimen types.
The findings support the tool's relevance in clinical settings, emphasizing its potential in guiding treatment decisions.

Implication

Analysis shows accuracy of tissue of origin prediction in non-CUP specimens, highlighting the tool's validation.

Abstract

Specimen selection for GPSai model training and validation. A total of 201,612 non-CUP specimens were used to train the model, 21,106 non-CUP specimens and 443 CUP specimens were used for retrospective validation, 6,820 TCGA cases were used for external validation, and 72,421 non-CUP and 3,850 CUP specimens were used for prospective validation, respectively.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Ghani et al. (2025) studied this question.

synapsesocial.com/papers/68bb49cc6d6d5674bccffaab https://doi.org/10.1158/2767-9764.30022019

View Full Paper

Ask AI

Bookmark

Share

Figure 1 from GPSai: A Clinically Validated AI Tool for Tissue of Origin Prediction during Routine Tumor Profiling

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure 1 from GPSai: A Clinically Validated AI Tool for Tissue of Origin Prediction during Routine Tumor Profiling

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading