Observational analysis shows GPSai improves tumor type prediction accuracy, highlighting its value in clinical settings.
Threshold selection for GPSai. The dashed line at 0.55 indicates the threshold determined to optimize both CUP call rate (green line) and hierarchical positive predictive value (hPPV, blue line) for metastatic cases. A GPS score ≥0.55 indicates high confidence in the tumor type prediction and will be included on the molecular report.
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Ghani et al. (2025) studied this question.
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