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September 5, 2025Chinese Medical JournalOpen Access

CircRERE promotes myocardial ischemia/reperfusion injury by increasing UHRF1 mRNA decay through targeting PUM2 to reduce Drp1 promoter methylation

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Authors

SFShihui FuYNYan NiePPPing Ping

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Overview

Experimental analysis shows circRNA RERE drives oxidative stress and mitochondrial dysfunction in I/R models, suggesting a pathway for therapeutic intervention.

Key Points

  • CircRERE knockdown reduced ROS levels by 39.5% and improved mitochondrial health.
  • The study highlights a 3.1-fold increase in CircRERE expression during myocardial I/R injury.
  • RNA immunoprecipitation validated interactions between CircRERE, PUM2, and UHRF1.
  • Targeting the CircRERE-UHRF1-Drp1 axis offers a potential new approach for myocardial I/R injury treatment.

Cite This Study

Fu et al. (2025) studied this question.

synapsesocial.com/papers/68bb49cc6d6d5674bccffad8https://doi.org/10.1097/cm9.0000000000003757
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CircBCL2L13 attenuates cardiomyocyte oxidative stress and apoptosis in cardiac ischemia‒reperfusion injury via miR‐1246/PEG3 signaling2024 · 8 citations
  2. 2CircDiaph3 aggravates H/R-induced cardiomyocyte apoptosis and inflammation through miR-338-3p/SRSF1 axis2024 · 5 citations
  3. 3Inhibition of circDGKZ ameliorates myocardial ischemia/reperfusion injury by targeting miR‐345‐5p/TLR42024 · 8 citations
  4. 4A Novel circRERE/miR-27a-3p/Caspase9 Signaling Axis Promotes Cardiomyocyte Apoptosis in Ischemic Myocardium: Insights from Epigallocatechin Gallate-Primed Exosomes2026 · 1 citations
  5. 5The Role of hsa_circ_0076767 in Mitochondrial Injury During Myocardial Ischemia/Reperfusion: a Focus on miR-140-3p and the Hypoxia-Inducible Factor-1α/β-Catenin Pathway.2026