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September 5, 2025Open Access

The Physiological Functions of the Brain in People with Substance use Disorder: A Systematic Review using PRISMA

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Authors

MSMatome M. SekhothaPNPholoso V. NgwanaMRMaanda Ravhutendele

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Overview

Systematic review highlights brain damage in those with substance use disorder, indicating risks of mental health issues.

Key Points

  • Using illicit drugs leads to significant brain damage, which may ultimately result in death if untreated.
  • A drop in the NAA/creatine ratio indicates reduced neuronal density and functional integrity in the brain.
  • The systematic review follows PRISMA guidelines to ensure comprehensive and detailed findings on brain physiology.
  • Adulterated drugs have detrimental effects on the morphology of the brain, emphasizing the need for immediate medical help.

Cite This Study

Sekhotha et al. (2025) studied this question.

synapsesocial.com/papers/68bb49d26d6d5674bccfffb4https://doi.org/10.5772/intechopen.1010039
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