This process utilizes N-fluorobenzenesulfonimide to achieve regioselective desaturation and imidation, demonstrating high functional group tolerance.
We demonstrate a copper-catalyzed regioselective cascade oxidative desaturation and imidation of saturated heterocycles using N-fluorobenzenesulfonimide (NFSI) as both an oxidant and an imidating reagent. A broad range of substituted piperidones, lactams, and cyclic ketones with high functional group tolerance could be successfully utilized in this transformation. TEMPO-trap experiments, control experiments, and DFT calculations provided supporting evidence for the possible desaturation process.
No takes yet. Share an insight, caveat, or question.
Xu et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: