Expert Consensus on the Appropriateness of Saccharomyces cerevisiae Hydrolysate in Obesity Management Using the RAND/UCLA Appropriateness Method

Background: Nutraceuticals are bioactive compounds that have shown promise in disease prevention and management. Due to their accessibility and affordability, they have gained increasing interest in obesity management. Some such nutraceuticals are Saccharomyces cerevisiae hydrolysates. Despite this growing interest, clinical practice guidelines rarely address their use, leaving clinicians with limited direction of their usage in routine care. This study aimed to develop a general guidance statement on the appropriateness of a Saccharomyces cerevisiae hydrolysate using a RAND/UCLA consensus process. Methods: A multidisciplinary panel of nine experts was convened to evaluate the appropriateness of a Saccharomyces cerevisiae hydrolysate in various clinical scenarios related to obesity management. Results: The panel deemed the use a Saccharomyces cerevisiae hydrolysate, in combination with lifestyle modifications, as an appropriate intervention for managing obesity-related outcomes. This included its use in patients with specific comorbidities, as an adjunct to standard pharmacotherapy, and in a set of selected clinical scenarios. Conclusions: Combining practitioners' insights with available data, the panel reached consensus that a Saccharomyces cerevisiae hydrolysate represents an appropriate intervention in a range of clinical scenarios for obesity management.