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September 5, 2025npj Biofilms and MicrobiomesOpen Access

Microbiome meets immunotherapy: unlocking the hidden predictors of immune checkpoint inhibitors

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Authors

LHLihaoyun HuangHYHaijun YuCZChunyan Zhang

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Overview

Analysis reveals microbiome influences treatment outcomes in cancer, suggesting vital predictors for immunotherapy success.

Key Points

  • Microbiome diversity correlates with improved progression-free survival in cancer patients receiving immunotherapy.
  • Viral status, especially from hepatitis B and human papillomavirus, significantly predicts treatment response rates.
  • Bacterial enrichment is linked to enhanced survival rates in patients with hepatobiliary and lung cancers.
  • Multi-microbiome models outperform traditional predictors in forecasting outcomes of immune checkpoint inhibitors.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68bb4dfb6d6d5674bcd026a5https://doi.org/10.1038/s41522-025-00819-2
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