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September 5, 2025Open Access

Frequency and Impact of Somatic Co-occurring Mutations on Post-Transplant Outcomes in Acute Myeloid Leukemia: A Multicenter Registry Analysis on Behalf of the EBMT ALWP

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Authors

ABAli BazarbachiJGJacques‐Emmanuel GalimardIDIman Abou Dalle

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Overview

Registry analysis reveals somatic mutations affect overall survival and leukemia-free survival in AML, suggesting distinct mutation groups.

Key Points

  • Patients with somatic mutations in AML experience varied overall survival outcomes post-transplant.
  • Somatic mutations such as TP53 negatively impact leukemia-free survival and overall survival in allografted patients.
  • Allogeneic hematopoietic cell transplantation can overcome adverse risks associated with certain mutation groups.
  • Next generation sequencing identified groups of mutations that carry distinct prognostic implications for AML patients.

Cite This Study

Bazarbachi et al. (2025) studied this question.

synapsesocial.com/papers/68bb4e016d6d5674bcd026d2https://doi.org/10.21203/rs.3.rs-7375987/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic impact of co-occurring mutations in NPM1-mutated Acute Myeloid Leukemia2025
  2. 2Impact of Somatic Gene Mutations on Prognosis Prediction in De Novo AML: Unraveling Insights from a Systematic Review and Meta-Analysis2025 · 1 citations
  3. 3Impact of induction response and co-mutations on transplant outcomes in AML with myelodysplasia-related gene mutations: A multicenter retrospective study2025
  4. 4Prognostic impact of clinico-genetic characteristics and donor types in <i>NPM1</i> -mutated AML undergoing allogeneic hematopoietic stem cell transplantation2026
  5. 5Acute Myeloid Leukaemia with Normal Cytogenetics and NPM1-Mutation: Impact of Mutation Topography on Outcomes2024