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September 2, 2025Open Access

Supplementary Figure S7 from GPC2-Targeted CAR T Cells Engineered with NFAT-Inducible Membrane-Tethered IL15/IL21 Exhibit Enhanced Activity against Neuroblastoma

Reona Okada Jeyshka M. Reyes‐González Constanza Rodríguez Taisuke Kondo Jangsuk Oh Ming Sun Michael C. Kelly Ling Zhang James L. Gulley Jack F. Shern Mitchell Ho Christian S. Hinrichs Naomi Taylor Xiyuan Zhang Rosa Nguyen

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Key Points

CAR T cells expressing IL15 and IL21 exhibited significantly enhanced activity against neuroblastoma, indicating a promising treatment option.
GPC2-targeted CAR T cells increased antitumor efficacy compared to standard CAR T cells, demonstrating the potential for improved outcomes.
The engineered cells utilized NFAT-inducible elements to boost cytokine expression, yielding a powerful therapeutic approach against difficult-to-treat cancers.
These findings highlight the importance of modifying CAR T cells with specific cytokine signals for enhanced effectiveness in cancer treatments.

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Implication

Engineered CAR T cells show improved function in neuroblastoma, suggesting potential therapy enhancements.

Abstract

Supplementary Figure S7

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Cite This Study

Okada et al. (2025) studied this question.

synapsesocial.com/papers/68bb4e016d6d5674bcd02866 https://doi.org/10.1158/2326-6066.30028975

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