What type of study is this?

This is a Animal Study study (also classified as: Observational).

DNAH10 mutation cause primary ciliary dyskinesia with defects of IDAf complex assembly and lung fibrosis manifestation

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Two families with primary ciliary dyskinesia exhibited DNAH10 mutations, suggesting impaired ciliary function and lung fibrosis.

Loss of DNAH10 function leads to defective cilia assembly and results in primary ciliary dyskinesia and pulmonary fibrosis.
Dnah10 knockout mice showed PCD symptoms, including chronic respiratory issues, confirming the gene's critical role in ciliary function.
Altered expression of ciliary proteins such as CFAP57 and DYNLL1 correlates with DNAH10 mutations and ciliary dysfunction.
These findings enhance understanding of ciliopathy mechanisms, indicating potential targets for therapeutic interventions.

Zheng et al. (2025) studied this question.

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View Full Paper

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Authors

Two families with primary ciliary dyskinesia exhibited DNAH10 mutations, suggesting impaired ciliary function and lung fibrosis.

Loss of DNAH10 function leads to defective cilia assembly and results in primary ciliary dyskinesia and pulmonary fibrosis.
Dnah10 knockout mice showed PCD symptoms, including chronic respiratory issues, confirming the gene's critical role in ciliary function.
Altered expression of ciliary proteins such as CFAP57 and DYNLL1 correlates with DNAH10 mutations and ciliary dysfunction.
These findings enhance understanding of ciliopathy mechanisms, indicating potential targets for therapeutic interventions.

Zheng et al. (2025) studied this question.

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