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September 5, 2025Frontiers in PediatricsOpen Access

Gut microbiota characteristics and therapeutic effects of fecal microbiota transplantation in children with autism spectrum disorder in central China: a combined cross-sectional and prospective study

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Authors

RWRui WuTXTeng XuYGYunkai Guo

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Overview

Combined cross-sectional and prospective analysis shows improved gut microbiota and clinical symptoms in children with autism spectrum disorder, suggesting fecal microbiota transplantation is effective.

Key Points

  • Children with autism spectrum disorder exhibited reduced microbial diversity, affecting gut health and symptoms.
  • Following fecal microbiota transplantation, significant clinical improvements were noted in core ASD symptoms and gastrointestinal issues.
  • The study utilized a streamlined fecal microbiota transplantation protocol with pediatric donors over three days.
  • This approach underscores the potential for microbiota-targeted interventions in autism spectrum disorder treatment.

Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/68bb5f3e6d6d5674bcd03321https://doi.org/10.3389/fped.2025.1648471
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  4. 4Composition of Gut Microbiota in Children with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis2020 · 361 citations