Functional loss of NMUR-3 reduces survival during heat shock in C. elegans, suggesting autophagy's role in thermal tolerance.
Neuromedin U receptors (NMURs) represent a class of evolutionarily conserved G-protein-coupled receptors that play a pivotal role in a variety of physiological processes. However, the role of NMURs in the heat shock response has yet to be elucidated. Using the nematode Caenorhabditis elegans as a model system, we demonstrate herein that functional loss of NMUR-3 results in reduced survival upon heat shock. The regulation of thermal tolerance by NMUR-3 is dependent on AMPK. Furthermore, our data demonstrate that NMUR-3 activates autophagy via AMPK, thereby contributing to protection against heat shock. The results of this study suggest that NMUR-3 is crucial for thermal tolerance in C. elegans.
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He et al. (2025) studied this question.
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