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September 5, 2025Endokrynologia PolskaOpen Access

Differential expression of microRNA-3127-5p and its molecular mechanisms in polycystic ovary syndrome

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Authors

HZHongjuan ZhangLPLing PengLYLei Yao

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Overview

Analysis reveals microRNA-3127-5p alters ferroptosis in granulosa cells, suggesting implications for PCOS management.

Key Points

  • Elevated microRNA-3127-5p impairs cell viability and promotes ferroptosis in granulosa cells.
  • Quantitative PCR confirmed higher levels of microRNA-3127-5p in serum and granulosa cells from PCOS patients.
  • Bioinformatics identified SORBS1 as a target of microRNA-3127-5p, influencing cell behavior.
  • Downregulation of microRNA-3127-5p improved cell survival and reduced oxidative stress markers.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68bb5f586d6d5674bcd03750https://doi.org/10.5603/ep.104875
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