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September 2, 2025International Journal of Molecular SciencesOpen Access

Machine Learning Integration of Bulk and Single-Cell RNA-Seq Data Reveals Cathepsin B as a Central PANoptosis Regulator in Influenza

Bin Liu Lin Zhu Caijuan Zhang Dunfang Wang Haifan Liu Jingwei Liu Jingwei Sun Xue Feng Weipeng Yang

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Key Points

Cathepsin B emerges as a central regulator of PANoptosis during influenza A virus infection, impacting lung injury.
Analysis revealed that increased PANoptosis activity is predominantly found in macrophages and neutrophils.
The study utilized machine learning algorithms on bulk and single-cell RNA sequencing data to identify regulatory genes.
Targeting cathepsin B may offer a promising therapeutic approach to mitigate influenza-induced immunopathology.

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Implication

Integration of RNA sequencing data highlights cathepsin B's role in PANoptosis in inflammation, suggesting new therapeutic strategies.

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Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68c1824b9b7b07f3a060ea5e https://doi.org/10.3390/ijms26178533

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