Analysis uncovers significant regional disparities in sedative compounds and volatile profiles in ZSS, indicating quality variations based on production areas.
Ziziphi Spinosae Semen (ZSS) has significant medicinal value, and its growing environment critically influences medicinal component accumulation. We analyzed 10 ZSS samples from six major Chinese production areas, identifying 2994 metabolites while exploring tranquilizing constituents and volatiles. Lipids and amino acids were the primary nutrients, while terpenoids were the most abundant class of secondary metabolites. Volatile profiling revealed characteristic sour-fruity-herbaceous flavors, with GS-QY samples showing the highest volatile content. HB-XT and LN-CY samples accumulated the most sedative compounds (jujubosides A/B, spinosin). These findings demonstrate production regions significantly influence ZSS’s medicinal/aromatic profiles, supporting targeted product development.
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Jia et al. (2025) studied this question.
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