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September 2, 2025Open Access

Figure S5 from Discovery of BMS-986408, a First-In-Class Dual DGKα and DGKζ Inhibitor that Unleashes PD-1 Checkpoint and CAR T-cell Immunotherapies

Michael Wichroski Si-Qi Liu Lauren M. Zasadil Joseph L. Benci Patrick C. Gedeon Kendall J. Condon Suhasini Joshi Shana Posy Patrick Carlson Alison Maier Jiao Shen Rakeeb Kureshi Yuka Amako Tai Wang Ryan L. Powles Yanyun Li Tho Lai Igor Katsyv Hongchen Qiu Huilin Qi Jessica Wong Dandan Zhao Dana Banas Joelle M. Onorato Gregory Locke Xueer Chen Wen‐Chi Chou Erica Cook Abigail E. Witt Christopher M. Barbieri Hong Zhang Jonathan B. Olsen Alba Font‐Tello Eugene Drokhlyansky Denise C. Grünenfelder Louis Chupak Tyler A. Longmire Jon C. Jones Travis J. Hollmann David Kugler John N. Feder Raphael Bueno John C. Wain Pallavur Sivakumar Yu Liu Stephanie K. Dougan Cloud P. Paweletz David A. Barbie Emma Lees

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Key Points

Inhibition of DGKα and DGKζ may enhance the effectiveness of PD-1 immunotherapy.
Phosphoproteomics analysis showed specific protein modifications related to dual versus mono-inhibition.
The study focuses on first-in-class inhibitors that target key pathways in immunotherapy.
Understanding the role of these inhibitors could inform future strategies for cancer treatment.

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Implication

Phosphoproteomics analysis reveals effects of DGK inhibition on PD-1 checkpoint and CAR T-cell therapies.

Abstract

Fig. S5. Phosphoproteomics analysis of DGKα/ζ dual- and mono- inhibition.

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Cite This Study

Wichroski et al. (2025) studied this question.

synapsesocial.com/papers/68c182609b7b07f3a060f5b2 https://doi.org/10.1158/2326-6066.30029419

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S4 from Discovery of BMS-986408, a First-In-Class Dual DGKα and DGKζ Inhibitor that Unleashes PD-1 Checkpoint and CAR T-cell Immunotherapies2025
2Figure S1 from Discovery of BMS-986408, a First-In-Class Dual DGKα and DGKζ Inhibitor that Unleashes PD-1 Checkpoint and CAR T-cell Immunotherapies2025
3Figure S2 from Discovery of BMS-986408, a First-In-Class Dual DGKα and DGKζ Inhibitor that Unleashes PD-1 Checkpoint and CAR T-cell Immunotherapies2025
4Figure S7 from Discovery of BMS-986408, a First-In-Class Dual DGKα and DGKζ Inhibitor that Unleashes PD-1 Checkpoint and CAR T-cell Immunotherapies2025
5Figure S3 from Discovery of BMS-986408, a First-In-Class Dual DGKα and DGKζ Inhibitor that Unleashes PD-1 Checkpoint and CAR T-cell Immunotherapies2025

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Data from Discovery of BMS-986408, a First-In-Class Dual DGKα and DGKζ Inhibitor that Unleashes PD-1 Checkpoint and CAR T-cell Immunotherapies2025
Design, Synthesis, and T Cell Checkpoint Combination Potential Of First-In-Class DGKα/ζ Inhibitor BMS-9864082025
Discovery of INCB191358: A Potent and Selective DGKα/ζ Dual Inhibitor2026