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Analysis reveals histomorphology differences in nevi, highlighting potential genomic modeling implications.
Histomorphology of two ‘nevi’ in the investigative cohort with high bivariate genomic model scores. NAE2 shows an asymmetrical compound tumor on low power (A), with irregular sized nests of melanocytes at the dermoepidermal junction and in dermis, displaying a lack of maturation on higher power (B); NAE50 shows a compound tumor devoid of architectural atypia at low power (C), with some superficial dermal cytological atypia present along with smaller, more mature nevoid melanocytes at the deep aspect at high power (D).
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Vergara et al. (2025) studied this question.
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