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Analysis of a bivariate genomic model reveals an optimal cut-off for malignancy in melanocytic tumors, indicating improved diagnostic accuracy.
Boxplot of scores from the bivariate genomic model in discovery and validation. The optimal cut-off that maximises the difference between true positive rate (TPR) and false positive rate (FPR) corresponding to the Youden index is identified at 0.65. Red line indicates the optimal cut-off.
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Vergara et al. (2025) studied this question.
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