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September 10, 2025Frontiers in Pharmacology0 citationsOpen Access

Metabolic State and Resuscitation of Antibiotic-Tolerant Persister Cells

Differential carbon source utilization drives metabolic state and resuscitation in antibiotic-tolerant persister cells

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Authors

YSYufei SunSRSweta RoyQYQingbo Yang

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Overview

Observational analysis of persister cell metabolism in Escherichia coli reveals differences based on carbon source, indicating metabolic adaptations for survival.

Key Points

  • Persister cells showed significant metabolic shutdown, demonstrating delayed labeling dynamics compared to normal cells.
  • When using glucose, persister cells exhibited reduced protein synthesis and slower metabolic pathways.
  • Under acetate conditions, nearly all intermediate pathways and amino acids faced pronounced labeling reductions.
  • Findings may inform future strategies aimed at combating persistent bacterial infections.

Cite This Study

Sun et al. (2025) studied this question.

synapsesocial.com/papers/68c183f89b7b07f3a060fbf1https://doi.org/10.3389/fphar.2025.1634627
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