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September 10, 2025Frontiers in GeneticsOpen Access

Multi-omics integration uncovers key transcriptional regulators in triple-negative breast cancer spatial heterogeneity

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Authors

NZNing ZhangYZYe ZhangRYRui-Fei Yang

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Overview

Comprehensive spatial atlas highlights significant variations in cell types and transcription factors in TNBC, suggesting therapeutic targets.

Key Points

  • Spatial analysis of triple-negative breast cancer revealed notable heterogeneity in cell types and distributions.
  • The study identified key transcription factors, including TFF3 and RARG, that regulate epithelial cells in TNBC.
  • Multi-omics integration using single-cell RNA sequencing and spatial transcriptomics mapped the tumor microenvironment.
  • Findings suggest potential therapeutic targets through receptor-ligand interactions linked to enhanced tumor aggression.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68c183f89b7b07f3a060fc65https://doi.org/10.3389/fgene.2025.1614254
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